Examining the genes in aging cells and tissues
Seq-Scope: Microscopic Examination of Spatial Single Cell Transcriptome in Cell and Tissue Senescence
This study is testing a new technology called Seq-Scope that helps scientists look closely at all the genes in aging cells, which could give us better insights into how aging affects your body and help improve health as we get older.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project ID | NIH-10915721 on NIH RePORTER |
What this research studies
This research focuses on a new technology called Seq-Scope, which allows scientists to examine all genes expressed in cells and tissues at a microscopic level. By using a method known as spatial barcoding, Seq-Scope captures RNA from tissue samples with high resolution, providing detailed information about gene expression in aging cells. This approach aims to overcome limitations of traditional methods that can only analyze a few genes at a time, enabling a more comprehensive understanding of cellular aging and senescence. Patients may benefit from insights gained about how aging affects their cells and tissues.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals experiencing age-related health issues or those interested in the biological mechanisms of aging.
Not a fit: Patients with acute conditions unrelated to aging or cellular senescence may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to breakthroughs in understanding and treating age-related conditions by providing detailed insights into cellular aging processes.
How similar studies have performed: Other research has shown success with similar spatial transcriptomics approaches, but Seq-Scope represents a novel advancement in this field.
Where this research is happening
Ann Arbor, United States
- University of Michigan at Ann Arbor — Ann Arbor, United States (Active)
Researchers
- Principal investigator: Lee, Jun Hee — University of Michigan at Ann Arbor
- Study coordinator: Lee, Jun Hee
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.