Examining the effects of certain industrial chemicals on brain development using human cell models
Investigating neurodevelopmental toxicity of perfluoroalkyl acids and their derivatives in human brain organoids models
This study is looking at how certain harmful chemicals found in the environment might affect the brain development of unborn babies, using special lab models to see how these substances can change the way brain cells grow and work, which could lead to learning and behavior problems in kids.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project ID | NIH-10992635 on NIH RePORTER |
What this research studies
This research investigates how per- and polyfluoroalkyl substances (PFAS), common environmental pollutants, affect brain development, particularly in fetuses. By using advanced human cell models, including brain organoids, the study aims to understand the molecular mechanisms by which PFAS may disrupt the growth and function of neural progenitor cells. The research focuses on how these chemicals can alter gene expression and impact the formation of brain networks, which could lead to neurodevelopmental issues in children.
Who could benefit from this research
Good fit: Ideal candidates for this research are pregnant individuals or those planning to conceive, particularly those with known exposure to PFAS.
Not a fit: Patients who are not pregnant or do not have a history of PFAS exposure may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and prevention of neurodevelopmental disorders linked to environmental toxins.
How similar studies have performed: Previous research has indicated that PFAS exposure can lead to neurodevelopmental issues, suggesting that this approach may yield significant insights.
Where this research is happening
La Jolla, United States
- University of California, San Diego — La Jolla, United States (Active)
Researchers
- Principal investigator: Iakoucheva, Lilia M — University of California, San Diego
- Study coordinator: Iakoucheva, Lilia M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.