Examining how legalizing recreational cannabis affects opioid use and overdoses.

CE24-012 - The Impact of Recreational Cannabis Legalization on Substance Use Outcomes

NIH-funded research Northwestern University at Chicago · NIH-10993984

This study looks at how legalizing recreational cannabis affects the use of opioids and overdose rates in the U.S., helping us understand how these laws might change how people manage pain and use substances.

Quick facts

Grant typeR01 grant
Study typeNIH-funded research
Funding institutionNorthwestern University at Chicago NIH-funded
Lab location1 site (Chicago, United States)
Project IDNIH-10993984 on NIH RePORTER

What this research studies

This research investigates the effects of recreational cannabis legalization on opioid use and overdose rates across the United States. It aims to understand how these policies influence individuals' choices regarding pain management and substance use. By utilizing a nationally representative survey and combining it with nationwide overdose data, the study will analyze changes in both non-fatal and fatal overdoses. The research team, composed of experts in substance use policy and addiction medicine, will employ advanced statistical methods to ensure robust findings that can guide public health interventions.

Who could benefit from this research

Good fit: Ideal candidates for this research include individuals living in states where recreational cannabis is legal and who may be using opioids for pain management.

Not a fit: Patients who do not reside in states with legalized recreational cannabis or those who do not use opioids may not benefit from this research.

Why it matters

Potential benefit: If successful, this research could provide valuable insights that help shape effective policies to reduce opioid misuse and overdose deaths.

How similar studies have performed: Previous research has indicated potential benefits of cannabis legalization on reducing opioid use, suggesting that this approach may yield significant findings.

Where this research is happening

Chicago, United States

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.