Examining how heart medications are used in cardiac surgery
Official title: COmparing iNoTRope prACtice variaTION in Cardiac Surgery (CONTRACTION-CS)
Funded at University of Michigan at Ann Arbor · NIH-10999426 · Data updated 2026-11-12
This study is looking at how heart medications called inotropes are used to help patients recover after heart surgery, so we can find the best ways to use them safely and effectively for everyone.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project start | December 15, 2023 |
| Project end | November 30, 2027 |
| Funding year | 2025 |
| Award (this year) | $619,114 |
| NIH project number | 5R01HL167790-02 |
| Project ID | NIH-10999426 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults undergoing cardiac surgery who may require inotropic support during their recovery.
✕Less likely to help
Patients who are not undergoing cardiac surgery or those who do not require inotropic medications will likely not benefit from this research.
What this research studies
This research investigates the use of inotropic medications, which help improve heart function during recovery from cardiac surgery. It aims to understand how these medications are applied across different hospitals and how their use can vary based on individual patient needs. By analyzing data from a large population of cardiac surgery patients, the study seeks to identify when inotropes are beneficial and when they may pose risks, such as increased mortality or complications. The goal is to create a more standardized and evidence-based approach to inotrope use in cardiac surgery.
Why it matters
Potential benefit: If successful, this research could lead to improved patient outcomes by optimizing the use of heart medications during and after cardiac surgery.
How similar studies have gone: Previous research has shown that standardizing medication practices can lead to improved patient outcomes, suggesting that this approach may also be effective for inotropic medications in cardiac surgery.
Where this research is happening
-
University of Michigan at Ann Arbor
Ann Arbor, United States Active
Researchers
- Principal investigator: Mathis, Michael Robert — University of Michigan at Ann Arbor
- Study coordinator: Mathis, Michael Robert
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.