NIH-funded research R01 grant

Examining how exposure to threats affects emotional responses and self-harm in children

Official title: Longitudinal examination of emotional reactivity and reactive aggression linking threat exposure with childhood self-injurious thoughts and behaviors

Funded at Research Triangle Institute · NIH-10914293 · Data updated 2026-11-12

This study is looking at how facing scary or upsetting situations might lead to self-harm thoughts and actions in young children, and it aims to find early signs that could help us understand and support their mental health better.

More Aggression research and trials

Quick facts

Grant typeR01 grant
Study typeNIH-funded research
Funding institutionResearch Triangle Institute
NIH-funded
Lab location1 site (Research Triangle Park, United States)
Project startSeptember 1, 2023
Project endJune 30, 2028
Funding year2024
Award (this year)$845,310
NIH project number5R01MH131565-02
Project IDNIH-10914293 on NIH RePORTER

Who could benefit from this research

Could help

Ideal candidates for this research include children aged 0-11 who have experienced threats or negative events.

Less likely to help

Patients who are older than 11 years or who have not experienced any form of threat may not benefit from this research.

What this research studies

This research investigates the relationship between exposure to threats and the development of self-injurious thoughts and behaviors (STBs) in children. It aims to understand how emotional reactivity and reactive aggression may increase the risk of STBs following negative experiences. By focusing on young children, the study seeks to identify early warning signs and risk factors that could lead to self-harm. The research will involve longitudinal assessments to track emotional responses and behaviors over time, providing valuable insights into the mental health of youth.

Why it matters

Potential benefit: If successful, this research could lead to earlier identification and intervention strategies for children at risk of self-harm.

How similar studies have gone: Previous research has shown promising results in understanding the impact of threat exposure on adolescent mental health, but this specific focus on younger children is relatively novel.

Where this research is happening

  • Research Triangle Institute
    Research Triangle Park, United States
    Active

Researchers

  • Principal investigator: Oppenheimer, Caroline — Research Triangle Institute
  • Study coordinator: Oppenheimer, Caroline

Related research

Other NIH-funded projects on the same topics.

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.