Examining how environmental toxins affect Alzheimer's disease risk in people with diabetes.
Official title: Impact of environmental toxicants on AD and ADRD risk in the Diabetes Prevention Program Outcomes study AD/ADRD project
Funded at Columbia University Health Sciences · NIH-10973888 · Data updated 2026-11-12
This study is looking at how certain harmful chemicals in our environment might affect the chances of developing Alzheimer's and related memory problems in people with prediabetes and type 2 diabetes, and it involves tests and samples from participants to better understand this connection.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | September 30, 2024 |
| Project end | August 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $2,533,483 |
| NIH project number | 1U01AG088684-01 |
| Project ID | NIH-10973888 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with prediabetes or type 2 diabetes who are concerned about their risk for Alzheimer's disease.
✕Less likely to help
Patients without diabetes or those who do not have concerns about Alzheimer's disease may not benefit from this research.
What this research studies
This research investigates the impact of environmental toxicants on the risk of Alzheimer's disease (AD) and related dementias (ADRD) among individuals participating in the Diabetes Prevention Program Outcomes Study. By analyzing a diverse group of participants with prediabetes and type 2 diabetes, the study will utilize advanced techniques to measure various environmental chemicals and their potential effects on brain health. Participants will undergo cognitive assessments and provide biological samples to help uncover the molecular mechanisms linking these toxicants to dementia risk.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and prevention strategies for Alzheimer's disease and related dementias in at-risk populations.
How similar studies have gone: Previous research has shown promising results in understanding the relationship between environmental factors and Alzheimer's disease, making this approach both relevant and potentially impactful.
Where this research is happening
-
Columbia University Health Sciences
New York, United States Active
Researchers
- Principal investigator: Luchsinger, Jose Alejandro — Columbia University Health Sciences
- Study coordinator: Luchsinger, Jose Alejandro
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.