Examining how diet and lifestyle changes affect diabetes risk
Lifestyle Interventions, metabolites, microbiome, and diabetes risk
This study is looking at how following a Mediterranean diet and making healthy lifestyle changes can help people aged 55 to 75 lower their chances of getting type 2 diabetes, by comparing those who get extra support for diet and exercise with those who receive regular advice.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Harvard School of Public Health NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10811573 on NIH RePORTER |
What this research studies
This research investigates the impact of a Mediterranean diet and lifestyle changes on the risk of developing type 2 diabetes (T2D) among individuals aged 55 to 75 who are not diabetic at the start. Participants are divided into two groups: one receiving intensive dietary and physical activity support aimed at weight loss, and the other receiving standard dietary advice. The study will track changes in body fat and diabetes incidence over six years, using advanced imaging techniques to measure fat distribution and analyzing metabolic markers related to diabetes risk.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults aged 55 to 75 who are non-diabetic and interested in making lifestyle changes to improve their health.
Not a fit: Patients who are already diagnosed with diabetes or those outside the age range of 55 to 75 may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to effective lifestyle interventions that significantly reduce the risk of developing type 2 diabetes in at-risk populations.
How similar studies have performed: Previous studies have shown that lifestyle interventions, particularly dietary changes, can effectively reduce diabetes risk, making this approach both promising and supported by existing evidence.
Where this research is happening
Boston, United States
- Harvard School of Public Health — Boston, United States (Active)
Researchers
- Principal investigator: Hu, Frank B — Harvard School of Public Health
- Study coordinator: Hu, Frank B
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.