Examining how childhood maltreatment affects DNA changes over time
Official title: Longitudinal examination of DNA methylation in maltreated children
Funded at Emma Pendleton Bradley Hospital · NIH-10470138 · Data updated 2026-11-12
This study is looking at how tough experiences in childhood, like abuse or neglect, can affect our genes and health later in life, helping us understand why some people might struggle with stress or health problems as they grow up.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Emma Pendleton Bradley Hospital NIH-funded |
| Lab location | 1 site (Riverside, UNITED STATES) |
| Project start | September 1, 2018 |
| Project end | August 31, 2025 |
| Funding year | 2022 |
| Award (this year) | $532,541 |
| NIH project number | 5R01HD095837-05 |
| Project ID | NIH-10470138 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are children who have experienced maltreatment and are between early and middle childhood.
✕Less likely to help
Patients who have not experienced childhood maltreatment may not receive direct benefits from this research.
What this research studies
This research investigates the long-term effects of childhood maltreatment on DNA methylation, which is a process that can influence how genes function. By studying children from early to middle childhood, the research aims to understand how experiences of maltreatment may lead to changes in the genes that regulate stress and immune responses. The study will track these changes over time to see how they relate to health outcomes and behavior. This could provide insights into the biological mechanisms that link early adversity to later health issues.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and interventions for health problems associated with childhood maltreatment.
How similar studies have gone: Other research has shown promising results in understanding the impact of early adversity on biological processes, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Emma Pendleton Bradley Hospital
Riverside, United States Active
Researchers
- Principal investigator: Parade, Stephanie Hart — Emma Pendleton Bradley Hospital
- Study coordinator: Parade, Stephanie Hart
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.