Examining changes in myelin lipids during neuroinflammation in multiple sclerosis
Official title: Investigating changes in myelin lipid composition during relapsing-remitting neuroinflammation
Funded at University of Texas San Antonio · NIH-11046562 · Data updated 2026-11-12
This study is looking at how the fats in the protective covering of nerves change during flare-ups and quiet times in multiple sclerosis, with the hope of finding new ways to help treat the condition.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas San Antonio NIH-funded |
| Lab location | 1 site (San Antonio, United States) |
| Project start | March 15, 2024 |
| Project end | February 28, 2026 |
| Funding year | 2025 |
| Award (this year) | $181,379 |
| NIH project number | 5R21NS137101-02 |
| Project ID | NIH-11046562 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with relapsing-remitting multiple sclerosis.
✕Less likely to help
Patients with other neurological conditions or those not diagnosed with multiple sclerosis may not benefit from this research.
What this research studies
This research investigates how the composition of lipids in the myelin sheath changes during episodes of neuroinflammation in multiple sclerosis (MS). By using advanced imaging techniques, the study aims to identify lipid alterations that occur during relapses and remissions of the disease. Understanding these changes could reveal new targets for treatment, particularly focusing on lipid-based therapies that have not been previously explored. The research seeks to address the urgent need for better therapeutic options for MS patients.
Why it matters
Potential benefit: If successful, this research could lead to new lipid-targeted therapies that improve treatment outcomes for patients with multiple sclerosis.
How similar studies have gone: While the approach of studying myelin lipids in MS is novel, previous research has shown that lipid-based treatments can reduce relapses, indicating potential for success in this area.
Where this research is happening
-
University of Texas San Antonio
San Antonio, United States Active
Researchers
- Principal investigator: Forsthuber, Thomas G. — University of Texas San Antonio
- Study coordinator: Forsthuber, Thomas G.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.