Examining cancer treatment differences in Black women with breast cancer in Detroit
Official title: Disparities in Immuno-oncology Outcomes in Detroit (DIODE)
Funded at Wayne State University · NIH-10879547 · Data updated 2026-11-12
This study is looking into why Black women in Detroit with a specific type of breast cancer might not respond as well to certain treatments, and it aims to understand how their unique genetics and immune systems play a role, so we can find better ways to help everyone.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Wayne State University NIH-funded |
| Lab location | 1 site (Detroit, United States) |
| Project start | September 5, 2024 |
| Project end | August 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $352,141 |
| NIH project number | 1P20CA290450-01 |
| Project ID | NIH-10879547 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are Black women diagnosed with HER2+ breast cancer who are receiving or have received treatment with anti-HER2 therapies.
✕Less likely to help
Patients who do not have HER2+ breast cancer or those outside the Black demographic may not benefit from this research.
What this research studies
This research investigates the reasons behind poorer cancer treatment outcomes for Black women with HER2+ breast cancer in Detroit. It focuses on understanding how genetic factors influence the immune response to anti-HER2 therapies, particularly monoclonal antibodies like trastuzumab. By analyzing racial differences in immune system genetics and the tumor environment, the study aims to identify biological factors that contribute to these disparities. The research involves a multidisciplinary team dedicated to developing equitable clinical strategies that consider both group and individual genetic variations.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment strategies for Black women with HER2+ breast cancer, ultimately enhancing their survival rates and quality of life.
How similar studies have gone: Previous research has indicated significant racial disparities in cancer treatment outcomes, suggesting that this approach could yield valuable insights and improvements.
Where this research is happening
-
Wayne State University
Detroit, United States Active
Researchers
- Principal investigator: Purrington, Kristen S. — Wayne State University
- Study coordinator: Purrington, Kristen S.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.