Evaluating treatments for organophosphate poisoning in children.
Official title: Pediatric model for evaluation of effects of and therapies for high level organophosphate anticholinesterase poisoning.
Funded at Mississippi State University · NIH-11083959 · Data updated 2026-11-12
This study is looking at how to better treat kids who get poisoned by certain harmful chemicals, using young animals to test new medicines that could help in emergencies.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mississippi State University NIH-funded |
| Lab location | 1 site (Mississippi State, United States) |
| Project start | August 1, 2021 |
| Project end | July 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $145,499 |
| NIH project number | 3U01NS123255-04S1 |
| Project ID | NIH-11083959 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are children and adolescents who may be at risk of exposure to organophosphate chemicals, whether through accidents or other incidents.
✕Less likely to help
Patients who are not children or adolescents, or those who have not been exposed to organophosphate poisoning, may not benefit from this research.
What this research studies
This research focuses on understanding the effects of organophosphate anticholinesterases, which are highly toxic chemicals that can cause severe poisoning, particularly in children. The study aims to develop a pediatric testing model to evaluate the safety and effectiveness of new therapies for treating organophosphate poisoning. By using juvenile animal models, the research seeks to identify better medical countermeasures that can be administered in emergency situations. The approach includes testing antidotes like atropine and oxime reactivators in a controlled setting that mimics real-life scenarios of exposure.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for children suffering from organophosphate poisoning, potentially saving lives and reducing long-term health effects.
How similar studies have gone: While there is limited information on pediatric therapies for organophosphate poisoning, previous studies have shown success in developing treatment paradigms for adult populations, indicating potential for similar advancements in children.
Where this research is happening
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Mississippi State University
Mississippi State, United States Active
Researchers
- Principal investigator: Chambers, Janice Elaine — Mississippi State University
- Study coordinator: Chambers, Janice Elaine
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.