Evaluating the use of whole blood for trauma resuscitation
1/2 Trauma Resuscitation with Group O Whole Blood Or Products (TROOP) Trial
The TROOP trial is looking at whether using whole blood instead of separate blood parts can help trauma patients who need a lot of blood transfusions, with the goal of improving their chances of recovery and reducing deaths from bleeding.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Alabama at Birmingham NIH-funded |
| Lab location | 1 site (Birmingham, United States) |
| Project ID | NIH-10925416 on NIH RePORTER |
What this research studies
The TROOP trial investigates the effectiveness and safety of using whole blood compared to traditional component blood therapy for trauma patients who need large volume blood transfusions. This multicenter clinical trial aims to determine if whole blood can improve outcomes for patients suffering from severe injuries, particularly in reducing preventable deaths due to hemorrhage. Participants will be randomly assigned to receive either whole blood or separated blood components during their treatment. The trial seeks to provide insights that could change current blood transfusion practices in emergency settings.
Who could benefit from this research
Good fit: Ideal candidates include trauma patients of all ages who are predicted to require large volume blood transfusions.
Not a fit: Patients who do not require blood transfusions or have contraindications for blood transfusion may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved survival rates and better recovery outcomes for trauma patients requiring blood transfusions.
How similar studies have performed: While there have been some observational studies on whole blood versus component therapy, this trial represents a more rigorous and systematic approach to evaluating this treatment method.
Where this research is happening
Birmingham, United States
- University of Alabama at Birmingham — Birmingham, United States (Active)
Researchers
- Principal investigator: Jansen, Jan O — University of Alabama at Birmingham
- Study coordinator: Jansen, Jan O
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.