Evaluating the use of bromocriptine to improve heart function in women after childbirth
(2/2) Randomized Evaluation of Bromocriptine In Myocardial Recovery THerapy for Peripartum Cardiomyopathy (REBIRTH)
This study is looking at whether adding bromocriptine, a medication that helps lower a hormone called prolactin, can improve heart function in women who have heart problems after giving birth, and it’s designed for women in North America who are experiencing this condition.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pittsburgh at Pittsburgh NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project ID | NIH-10903782 on NIH RePORTER |
What this research studies
This research investigates the effectiveness of bromocriptine, a medication that inhibits prolactin, in improving heart function for women suffering from peripartum cardiomyopathy (PPCM). The study will compare standard heart failure therapy with and without the addition of bromocriptine in a randomized controlled trial. By focusing on a diverse group of women in North America, the research aims to provide insights into how this treatment can enhance recovery outcomes. Participants will be monitored for improvements in heart function and overall health during the postpartum period.
Who could benefit from this research
Good fit: Ideal candidates for this research are women diagnosed with peripartum cardiomyopathy who are within the postpartum period.
Not a fit: Patients who are not experiencing peripartum cardiomyopathy or those who are beyond the postpartum period may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved heart recovery and reduced mortality rates for women with peripartum cardiomyopathy.
How similar studies have performed: Previous studies have shown promising results with bromocriptine in treating PPCM, but this specific randomized trial is novel in its approach within a North American cohort.
Where this research is happening
Pittsburgh, United States
- University of Pittsburgh at Pittsburgh — Pittsburgh, United States (Active)
Researchers
- Principal investigator: Abebe, Kaleab Z — University of Pittsburgh at Pittsburgh
- Study coordinator: Abebe, Kaleab Z
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.