Evaluating the function and metabolism of retinal cells in glaucoma using advanced imaging techniques
In Vivo Function and Metabolism Evaluation of Glaucomatous RGCs by Two-Photon Scanning Laser Ophthalmology
['FUNDING_R01'] · STANFORD UNIVERSITY · NIH-11055426
This study is looking at how the cells in your eye that help you see are affected by glaucoma, using a special imaging technique to watch them in action, so we can learn more about how to protect them and improve treatments for people with this condition.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | STANFORD UNIVERSITY (nih funded) |
| Locations | 1 site (STANFORD, UNITED STATES) |
| Trial ID | NIH-11055426 on ClinicalTrials.gov |
What this research studies
This research investigates the function and metabolism of retinal ganglion cells (RGCs) in glaucoma, a leading cause of irreversible blindness. Using a novel two-photon scanning laser ophthalmoscopy (2P-SLO) platform, researchers will perform non-invasive imaging to observe RGCs in real time, allowing for a better understanding of their physiology under different conditions. The study employs advanced imaging techniques and analysis protocols to explore the effects of intraocular pressure (IOP) on RGC health and the potential for neuroprotective treatments. By utilizing animal models that mimic both chronic and acute glaucoma, the research aims to uncover critical insights into RGC dysfunction and death.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals at risk for glaucoma or those diagnosed with the condition, particularly those experiencing elevated intraocular pressure.
Not a fit: Patients with other forms of vision impairment unrelated to glaucoma may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for glaucoma, potentially preserving vision for patients.
How similar studies have performed: Previous research using similar imaging techniques has shown promise in understanding retinal cell function, indicating that this approach may yield valuable insights.
Where this research is happening
STANFORD, UNITED STATES
- STANFORD UNIVERSITY — STANFORD, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: HU, YANG — STANFORD UNIVERSITY
- Study coordinator: HU, YANG
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.