Evaluating the effects of statins on dementia and disability in older adults
PREVENTABLE Trial Implementation Phase
This study is looking at how a moderate dose of a cholesterol-lowering medication called a statin might help prevent dementia and keep older adults aged 75 and up healthier for longer, especially those who don’t have heart disease or dementia.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Duke University NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project ID | NIH-10913418 on NIH RePORTER |
What this research studies
This research investigates how a moderate intensity statin can impact the development of dementia and improve disability-free survival among older adults aged 75 and above who do not have heart disease or dementia. The study will involve 20,000 community-dwelling participants and will assess both cardiovascular and cognitive outcomes. Researchers will also evaluate the tolerability of statins through participant reports and reasons for discontinuation. The trial aims to implement effective protocols for enrolling participants and monitoring outcomes efficiently.
Who could benefit from this research
Good fit: Ideal candidates for this research are community-dwelling individuals aged 75 years and older without a history of atherosclerotic coronary heart disease or dementia.
Not a fit: Patients who are younger than 75 years or those with existing cardiovascular disease or dementia may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new preventative strategies for dementia and improve the quality of life for older adults.
How similar studies have performed: Previous research has shown promising results in using statins for cardiovascular health, but this specific approach to dementia prevention is novel.
Where this research is happening
Durham, United States
- Duke University — Durham, United States (Active)
Researchers
- Principal investigator: Alexander, Karen P — Duke University
- Study coordinator: Alexander, Karen P
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.