Evaluating the best outcomes for therapies helping adolescents with substance use issues

Optimal Endpoints in Clinical Trials of Cognitive Behavioral Interventions for AOD: An Aggregate and Individual Patient Data Meta-Analysis

NIH-funded research Brown University · NIH-10907536

This study is looking at how well Cognitive Behavioral Therapy and similar treatments help teenagers who are dealing with alcohol and drug use, focusing on how these therapies can improve their coping skills and mental health, not just whether they stop using substances.

Quick facts

Grant typeR01 grant
Study typeNIH-funded research
Funding institutionBrown University NIH-funded
Lab location1 site (Providence, United States)
Project IDNIH-10907536 on NIH RePORTER

What this research studies

This research investigates the effectiveness of Cognitive Behavioral Therapy (CBT) and other related interventions for adolescents struggling with alcohol and other drug (AOD) use. By analyzing data from numerous previous studies, the project aims to identify the most meaningful outcomes for patients, such as improvements in coping behaviors and overall mental health, rather than just focusing on abstinence. The research employs advanced statistical methods to ensure a thorough understanding of how these therapies can best support young individuals in their recovery journey.

Who could benefit from this research

Good fit: Ideal candidates for this research are adolescents who are experiencing challenges related to alcohol and other drug use.

Not a fit: Patients who are not adolescents or those who do not have issues with alcohol or other drug use may not benefit from this research.

Why it matters

Potential benefit: If successful, this research could lead to improved treatment strategies that better address the needs of adolescents dealing with substance use issues.

How similar studies have performed: Previous research has shown promising results in using similar methodologies to evaluate the effectiveness of behavioral therapies for substance use disorders.

Where this research is happening

Providence, United States

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.