Evaluating the benefits of statins in older adults to prevent dementia and disability
PRagmatic EValuation of evENTs And Benefits of Lipid-lowering in oldEr Adults (PREVENTABLE)
This study is looking at whether statin medications can help older adults over 75 stay mentally sharp and avoid disabilities, and it’s designed to include a wide range of people in this age group who often haven't been part of similar research before.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Duke University NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project ID | NIH-10913405 on NIH RePORTER |
What this research studies
This research investigates the effects of statin medications on older adults, particularly those over 75 years old, to determine if they can help prevent dementia and disability. The study aims to fill the gap in clinical evidence for this age group, which has often been excluded from previous research due to higher rates of comorbidity and frailty. By using a placebo-controlled pragmatic clinical trial design, the research will assess cognitive and functional outcomes in a diverse population of older adults. Participants will be monitored for their health outcomes, focusing on survival free of dementia or persistent disability.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults aged 75 and above, particularly those at risk for cardiovascular disease and dementia.
Not a fit: Patients who are younger than 75 years or those without risk factors for cardiovascular disease or dementia may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide critical evidence on the effectiveness of statins in preventing cognitive decline and disability in older adults.
How similar studies have performed: This approach is novel as it focuses on older adults and evaluates non-CVD primary outcomes, addressing a significant gap in existing research.
Where this research is happening
Durham, United States
- Duke University — Durham, United States (Active)
Researchers
- Principal investigator: Alexander, Karen P — Duke University
- Study coordinator: Alexander, Karen P
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.