Evaluating new strategies to prevent tuberculosis in people living with HIV in Brazil
PREVINE-TB: PRevent: EValuating the implementation of NEw strategies for preventive TB among people living with HIV in Brazil
This study is looking to make it easier for people living with HIV in Brazil to get tested and treated for tuberculosis (TB) by using a new blood test that doesn’t require extra clinic visits and trying out different ways to help them stick to their treatment plans.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-10426171 on NIH RePORTER |
What this research studies
This research focuses on improving tuberculosis (TB) prevention among individuals living with HIV in Brazil, where TB rates are significantly higher in this population. The study will implement a new blood test, QFT+, to determine latent TB infection without requiring patients to return to the clinic, thus streamlining the process. Additionally, it will compare different adherence strategies to optimize the use of preventive therapy, including a new regimen that may be easier for patients to follow. By addressing barriers to treatment, the research aims to enhance the effectiveness of TB prevention efforts in HIV clinics.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults living with HIV in Brazil who are at risk for tuberculosis.
Not a fit: Patients who are not living with HIV or those who do not reside in Brazil may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could significantly reduce the incidence of tuberculosis among people living with HIV, improving their overall health outcomes.
How similar studies have performed: Previous research has shown promise in using innovative testing and treatment strategies for TB prevention in similar populations, indicating potential for success in this approach.
Where this research is happening
Baltimore, United States
- Johns Hopkins University — Baltimore, United States (Active)
Researchers
- Principal investigator: Golub, Jonathan E. — Johns Hopkins University
- Study coordinator: Golub, Jonathan E.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.