Evaluating new HIV vaccine strategies using nonhuman primates
Assessment of Clinical Grade Near-Native Cleavage-Independent Trimer Protein Compared to Membrane-Bound mRNA Expression Coupled with Glycan Deletion, Restoration and Heterologous Boosting
This study is testing new HIV vaccines using monkeys to see how well they work and how they can help the immune system fight off the virus, which is important for finding better ways to protect people from HIV.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Tulane University of Louisiana NIH-funded |
| Lab location | 1 site (New Orleans, United States) |
| Project ID | NIH-10709459 on NIH RePORTER |
What this research studies
This research focuses on developing effective HIV vaccines by utilizing nonhuman primates (NHPs) in preclinical studies. The Simian Vaccine Evaluation Units (SVEUs) will provide resources to assess candidate AIDS vaccines, allowing researchers to evaluate immune responses and vaccine efficacy. By conducting thorough evaluations, the study aims to identify approaches that enhance the effectiveness of vaccines in preventing or controlling HIV infection. This research is crucial for advancing our understanding of how to generate protective immune responses against HIV.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals at high risk for HIV infection who may benefit from new vaccine strategies.
Not a fit: Patients who are already HIV-positive or those who do not have a risk of HIV exposure may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of effective vaccines that prevent or control HIV infection in humans.
How similar studies have performed: Previous research using nonhuman primates has shown promise in developing effective vaccines for HIV, indicating that this approach has potential for success.
Where this research is happening
New Orleans, United States
- Tulane University of Louisiana — New Orleans, United States (Active)
Researchers
- Principal investigator: Aye, Pyone — Tulane University of Louisiana
- Study coordinator: Aye, Pyone
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.