Evaluating medication safety and effectiveness in children using real-world data
Official title: The development of a systematic approach to harness real-world evidence for the evaluation of medication safety and effectiveness in children
Funded at Brigham and Women's Hospital · NIH-10890198 · Data updated 2026-11-12
This study is looking to make sure that the medications given to children are safe and work well by using real health data to better understand how these medicines affect kids, especially when they are used in ways not originally intended.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | August 1, 2023 |
| Project end | July 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $168,051 |
| NIH project number | 5K08HD110600-02 |
| Project ID | NIH-10890198 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include children aged 0-21 who are prescribed medications, especially those receiving off-label prescriptions.
✕Less likely to help
Patients who are not receiving any medications or those outside the pediatric age range may not benefit from this research.
What this research studies
This research focuses on improving the safety and effectiveness of medications prescribed to children by utilizing real-world data collected from electronic health records and other sources. It aims to develop a systematic approach to evaluate medications that are often prescribed off-label, particularly in pediatric populations. The project will emulate randomized controlled trials using this data to generate real-world evidence about medication effects, addressing gaps in knowledge about pediatric medication use. By conducting rigorous studies, the research seeks to ensure that children receive medications that are both safe and effective for their specific age and health conditions.
Why it matters
Potential benefit: If successful, this research could lead to safer and more effective medication prescribing practices for children.
How similar studies have gone: Other research has shown success in using real-world data to evaluate medication safety and effectiveness, indicating that this approach is promising and not entirely novel.
Where this research is happening
-
Brigham and Women's Hospital
Boston, United States Active
Researchers
- Principal investigator: Savage, Timothy John — Brigham and Women's Hospital
- Study coordinator: Savage, Timothy John
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.