Evaluating management strategies for HIV treatment failure in Sub-Saharan Africa
A Randomized Clinical Trial to Evaluate Solutions for the Management of Virologic Failure for Individuals on TLD in Sub-Saharan Africa
This study is looking at how to help people in Sub-Saharan Africa who aren't responding well to their HIV medication by figuring out why that happens and creating personalized treatment plans just for them.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts General Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10875410 on NIH RePORTER |
What this research studies
This research investigates how to best manage individuals experiencing treatment failure while on a common HIV medication regimen in Sub-Saharan Africa. It focuses on understanding the reasons behind treatment failure, such as adherence issues and drug resistance, and aims to develop personalized care strategies. The study will utilize innovative tools like urine tests and genetic resistance testing to tailor treatment plans for patients. By involving diverse patient perspectives, the research seeks to improve overall treatment outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals over 21 years old who are currently on the TLD regimen and experiencing virologic failure.
Not a fit: Patients who are not on the TLD regimen or those who have not experienced treatment failure may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective management strategies for individuals with HIV, ultimately improving their health outcomes and quality of life.
How similar studies have performed: This approach is innovative and represents a novel effort to address treatment failure in HIV management, as similar comprehensive strategies have not been widely tested in this context.
Where this research is happening
Boston, United States
- Massachusetts General Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Mccluskey, Suzanne — Massachusetts General Hospital
- Study coordinator: Mccluskey, Suzanne
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.