Evaluating immune responses in experimental HIV vaccine trials
Immunologic evaluation of HIV-1 HVTN experimental medicine trials HVTN 307, HVTN 309 and HVTN312
This study is looking at how well different HIV vaccines can help your immune system make powerful antibodies to fight the virus, and it's for people who have taken part in specific HIV vaccine trials.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Duke University NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project ID | NIH-11078958 on NIH RePORTER |
What this research studies
This research focuses on analyzing immune responses in participants of HIV vaccine trials HVTN 307, HVTN 309, and HVTN 312. By examining blood samples and using advanced genomic techniques, the study aims to identify and enhance the development of broadly neutralizing antibodies (bnAbs) that can effectively combat HIV. Participants will contribute to understanding how different vaccine designs can stimulate the immune system to produce these critical antibodies. The goal is to gather insights that will lead to the creation of a more effective HIV vaccine by 2026.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who are at risk of HIV infection and are willing to participate in vaccine trials.
Not a fit: Patients who are already living with HIV or those who are not at risk for HIV infection may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of a more effective HIV vaccine, improving prevention strategies for individuals at risk of HIV infection.
How similar studies have performed: Previous research in similar vaccine trials has shown promise in developing effective strategies for eliciting immune responses against HIV.
Where this research is happening
Durham, United States
- Duke University — Durham, United States (Active)
Researchers
- Principal investigator: Haynes, Barton F. — Duke University
- Study coordinator: Haynes, Barton F.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.