Evaluating how well respiratory virus vaccines work in a diverse healthcare system
RFA-IP-22-004, Evaluating respiratory virus vaccine effectiveness in a large, diverse healthcare system
This study is looking at how well vaccines protect against respiratory viruses like the flu and COVID-19 by comparing vaccinated and unvaccinated patients who visit the doctor for these infections, and it's open to people who want to help us understand more about these viruses during flu season.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pittsburgh at Pittsburgh NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project ID | NIH-10953523 on NIH RePORTER |
What this research studies
This research investigates the effectiveness of vaccines against respiratory viruses, including influenza and COVID-19, by analyzing data from a large healthcare system. It aims to enroll 1,000 to 1,200 outpatients during the influenza season and an additional 400 to 900 if COVID-19 continues to be a concern. The study will use a test-negative case-control design to compare vaccinated and unvaccinated individuals who seek medical care for respiratory infections. Additionally, genetic sequencing will be performed on selected samples to monitor trends in viral strains.
Who could benefit from this research
Good fit: Ideal candidates for participation include outpatients aged 6 months and older who are seeking medical care for respiratory infections during the influenza season.
Not a fit: Patients who are not experiencing respiratory infections or who are not part of the specified age groups may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide valuable insights into vaccine effectiveness, helping to improve vaccination strategies and public health responses.
How similar studies have performed: Previous research has shown success in evaluating vaccine effectiveness using similar methodologies, indicating that this approach is well-established.
Where this research is happening
Pittsburgh, United States
- University of Pittsburgh at Pittsburgh — Pittsburgh, United States (Active)
Researchers
- Principal investigator: Zimmerman, Richard K — University of Pittsburgh at Pittsburgh
- Study coordinator: Zimmerman, Richard K
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.