Evaluating how well different rectal and vaginal medications work in the body
In Vitro Based Approaches to Evaluate the Bioequivalence of Locally-Acting Rectal and Vaginal Semi-Solid Drug Products
This study is looking at how well creams and suppositories work for treating conditions in the rectal and vaginal areas, with the goal of making it easier and cheaper for patients to get these important medications.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Northeastern University NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10908363 on NIH RePORTER |
What this research studies
This research focuses on understanding the effectiveness of locally-acting rectal and vaginal semi-solid drug products, such as creams and suppositories. It aims to identify key quality attributes of these products and develop specific in vitro tests to evaluate their performance. By studying how drugs permeate through mucosal membranes, the research seeks to improve the approval process for generic versions of these medications, which can be challenging due to their complexity. Patients may benefit from more accessible and affordable treatment options as a result of this work.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who require treatment for conditions affecting the rectal or vaginal areas and may benefit from improved drug formulations.
Not a fit: Patients with conditions that do not require locally-acting rectal or vaginal medications may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of more effective and affordable generic medications for rectal and vaginal conditions.
How similar studies have performed: While the specific approach of this research may be novel, previous studies have shown success in developing in vitro testing methods for other drug formulations.
Where this research is happening
Boston, United States
- Northeastern University — Boston, United States (Active)
Researchers
- Principal investigator: Shen, Jie — Northeastern University
- Study coordinator: Shen, Jie
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.