Evaluating how well a malaria vaccine works in children in Kenya
A systems immunology approach to evaluate malaria vaccine performance in endemic regions of Kenya
['FUNDING_U01'] · UNIV OF MASSACHUSETTS MED SCH WORCESTER · NIH-11016940
This study is looking at how well the RTS,S malaria vaccine works in children in Kenya who are at risk of malaria, by tracking their immune responses and infections after getting vaccinated, to find ways to make the vaccine even better for them.
Quick facts
| Phase | ['FUNDING_U01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIV OF MASSACHUSETTS MED SCH WORCESTER (nih funded) |
| Locations | 1 site (WORCESTER, UNITED STATES) |
| Trial ID | NIH-11016940 on ClinicalTrials.gov |
What this research studies
This research investigates the effectiveness of the RTS,S malaria vaccine in children living in malaria-endemic regions of Kenya. It aims to understand the immune responses of these children to the vaccine by following them through their vaccination schedule and monitoring for malaria infections. The study will utilize a systems immunology approach to evaluate how different immune factors influence vaccine performance. By analyzing the immune responses, researchers hope to identify ways to enhance the vaccine's efficacy in this population.
Who could benefit from this research
Good fit: Ideal candidates for this research are children aged 0 to 4 years living in malaria-endemic areas of Kenya.
Not a fit: Patients who are not living in malaria-endemic regions or are older than 4 years may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved malaria vaccine strategies that better protect children in endemic regions.
How similar studies have performed: Previous research has shown promise in understanding immune responses to vaccines, but this specific approach in children from endemic regions is novel.
Where this research is happening
WORCESTER, UNITED STATES
- UNIV OF MASSACHUSETTS MED SCH WORCESTER — WORCESTER, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MOORMANN, ANN M — UNIV OF MASSACHUSETTS MED SCH WORCESTER
- Study coordinator: MOORMANN, ANN M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.