Evaluating how human intestinal stem cells respond to inflammatory bowel disease factors
A Novel Planar Crypt Microarray for Real-Time Evaluation of Human Intestinal Stem Cell Fate
This study is looking at how the stem cells in your intestines respond to factors related to inflammatory bowel diseases like Crohn’s and ulcerative colitis, using a special device to watch them in action, with the goal of finding better ways to treat these conditions.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of North Carolina Chapel Hill NIH-funded |
| Lab location | 1 site (Chapel Hill, United States) |
| Project ID | NIH-10862538 on NIH RePORTER |
What this research studies
This research investigates the behavior of human intestinal stem cells (ISCs) in response to factors related to inflammatory bowel diseases (IBD) such as Crohn’s disease and ulcerative colitis. Using a novel planar crypt microarray device, researchers will live-image primary human colonic stem cells to observe their reactions to various IBD-related stimuli. The study aims to enhance our understanding of how these cells function and adapt in a more physiologically relevant environment, which could lead to better treatment strategies for IBD. By utilizing advanced techniques like CRISPR and bioinformatics, the research seeks to uncover the complex interactions that influence ISC fate and function.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults aged 21 and older who are diagnosed with inflammatory bowel diseases.
Not a fit: Patients with non-inflammatory bowel conditions or those under 21 years old may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved therapies for patients suffering from inflammatory bowel diseases.
How similar studies have performed: Previous research has shown success in using organoid models to study intestinal stem cells, indicating potential for this novel approach.
Where this research is happening
Chapel Hill, United States
- Univ of North Carolina Chapel Hill — Chapel Hill, United States (Active)
Researchers
- Principal investigator: Ok, Meryem Tyrrasch — Univ of North Carolina Chapel Hill
- Study coordinator: Ok, Meryem Tyrrasch
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.