Evaluating how exercise training affects heart health in heart failure patients using advanced imaging techniques.
Official title: Serial evaluation of cardioprotective effects of exercise training in heart failure using cardiac diffusion tensor MRI
Funded at Cleveland Clinic Lerner Com-Cwru · NIH-10848235 · Data updated 2026-11-12
This study is looking at how exercise can help improve heart health in people with heart failure by using special imaging to see changes in the heart while they do aerobic workouts, so we can better understand how to tailor exercise programs for each person.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cleveland Clinic Lerner Com-Cwru NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project start | November 4, 2022 |
| Project end | May 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $683,284 |
| NIH project number | 5R01HL151704-06 |
| Project ID | NIH-10848235 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with heart failure who are interested in participating in an exercise training program.
✕Less likely to help
Patients with severe comorbidities that prevent them from engaging in any form of exercise may not benefit from this research.
What this research studies
This research investigates the cardioprotective effects of exercise training in patients with heart failure by utilizing cardiac diffusion tensor MRI (DT-MRI). The study aims to monitor and evaluate changes in heart muscle structure and function as patients engage in aerobic exercise therapy. By employing this non-invasive imaging technology, researchers hope to better understand how exercise can halt or even reverse harmful changes in the heart's structure. This approach addresses the need for personalized exercise therapy by providing insights into individual responses to exercise.
Why it matters
Potential benefit: If successful, this research could lead to improved exercise therapy protocols that enhance heart function and quality of life for heart failure patients.
How similar studies have gone: Previous research has shown promising results in using exercise therapy for heart failure, but this specific approach utilizing DT-MRI is relatively novel.
Where this research is happening
-
Cleveland Clinic Lerner Com-Cwru
Cleveland, United States Active
Researchers
- Principal investigator: Nguyen, Christopher T — Cleveland Clinic Lerner Com-Cwru
- Study coordinator: Nguyen, Christopher T
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.