Evaluating early liver transplantation for patients with severe alcohol-related liver disease
4/4-American Consortium of Early Liver Transplantation-Prospective Alcohol-associated liver disease Cohort Evaluation (ACCELERATE-PACE)
This study is looking at how early liver transplants can help people with severe liver disease caused by alcohol, even before they’ve stopped drinking for six months, to make sure more patients get the care they need and improve their chances of recovery.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Methodist Hospital Research Institute NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project ID | NIH-10893429 on NIH RePORTER |
What this research studies
This research investigates the outcomes of early liver transplantation (ELT) for patients suffering from severe alcohol-associated liver disease (ALD). It involves a longitudinal cohort of patients who are evaluated for transplantation before the traditional six-month abstinence period. The study aims to refine selection criteria and management practices for these patients, addressing the variability in current practices and improving access to life-saving care. By analyzing treatment efficacy and predicting liver recompensation, the research seeks to enhance patient outcomes and organ utilization.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals over 21 years old with severe alcohol-associated liver disease who are being considered for early liver transplantation.
Not a fit: Patients with mild liver disease or those who do not meet the criteria for liver transplantation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide a pathway for earlier liver transplantation, potentially saving lives and improving recovery for patients with severe alcohol-related liver disease.
How similar studies have performed: Previous research has shown promising results with early liver transplantation approaches, but this study aims to establish more standardized practices in a field that has seen significant variability.
Where this research is happening
Houston, United States
- Methodist Hospital Research Institute — Houston, United States (Active)
Researchers
- Principal investigator: Ghobrial, Rafik Mark — Methodist Hospital Research Institute
- Study coordinator: Ghobrial, Rafik Mark
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.