Evaluating DNA repair gene variants in prostate cancer
Functional Evaluation and Interpretation of DNA Damage Repair Variants in Prostate Cancer
This study is looking at how certain genetic changes in DNA repair genes might affect prostate cancer in men with advanced stages of the disease, hoping to help tailor treatments based on each person's unique genetic makeup.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Sloan-Kettering Inst Can Research NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10922781 on NIH RePORTER |
What this research studies
This research investigates how specific genetic variants in DNA damage repair (DDR) genes affect prostate cancer, particularly in men with metastatic castration-resistant prostate cancer (mCRPC). By using advanced techniques like organoid technology and CRISPR gene editing, the study aims to identify whether these genetic changes lead to more aggressive cancer behavior and influence treatment responses. Patients may benefit from a better understanding of their cancer's genetic profile, which could inform personalized treatment strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are men diagnosed with metastatic castration-resistant prostate cancer or those with localized prostate cancer exhibiting DDR gene mutations.
Not a fit: Patients without any genetic variants in the DNA damage repair pathway or those with non-prostate cancers may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective, personalized treatment options for prostate cancer patients based on their genetic makeup.
How similar studies have performed: Previous research has shown promising results in understanding the role of DNA repair gene mutations in various cancers, suggesting that this approach could yield valuable insights.
Where this research is happening
New York, United States
- Sloan-Kettering Inst Can Research — New York, United States (Active)
Researchers
- Principal investigator: Sawyers, Charles L. — Sloan-Kettering Inst Can Research
- Study coordinator: Sawyers, Charles L.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.