Evaluating different types of dural grafts for brain surgery recovery
In vitro and in vivo assessments of xenogeneic cranial dura mater and naturally derived commercial dural grafts
This study is looking at different types of materials used in brain surgery to help prevent leaks and other problems, comparing new options to what’s already available, so that patients can have safer surgeries and better recoveries.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Florida NIH-funded |
| Lab location | 1 site (Gainesville, United States) |
| Project ID | NIH-10908340 on NIH RePORTER |
What this research studies
This research investigates the effectiveness of various dural grafts used in brain surgery to prevent complications such as cerebrospinal fluid leaks. It compares acellular xenogeneic grafts with commercially available natural grafts to determine which type elicits a better immune response and maintains structural integrity over time. The study involves both laboratory tests and experiments in a rat model to assess graft sealing strength, infection risk, and tissue healing. Patients may benefit from improved surgical outcomes and reduced complications from better graft materials.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients scheduled for neurosurgery who may require dural grafts.
Not a fit: Patients who are not undergoing neurosurgery or do not require dural grafts will not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to safer and more effective dural graft options for patients undergoing brain surgery.
How similar studies have performed: Previous research has shown promise in using xenogeneic grafts for various applications, suggesting potential success for this approach.
Where this research is happening
Gainesville, United States
- University of Florida — Gainesville, United States (Active)
Researchers
- Principal investigator: Williams, Lakiesha Nicole — University of Florida
- Study coordinator: Williams, Lakiesha Nicole
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.