Evaluating coronary artery calcium and troponin levels to improve heart disease prevention in older adults
Coronary Artery Calcium in the PRagmatic EValuation of evENTs And Benefits of Lipid lowering in the Elderly: CAC PREVENTABLE Ancillary Study
This study is looking at how certain heart tests can help doctors figure out which older adults might need cholesterol-lowering medications to better protect their heart health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Duke University NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project ID | NIH-10674482 on NIH RePORTER |
What this research studies
This research investigates how coronary artery calcium (CAC) scoring and high-sensitivity troponin (hs-Tn) levels can help predict the risk of atherosclerotic cardiovascular disease (ASCVD) in adults aged 75 and older. By analyzing these biomarkers in a large group of older adults participating in a clinical trial, the study aims to identify which individuals may benefit most from statin therapy. The approach combines advanced imaging and blood tests to provide a clearer picture of cardiovascular risk, potentially leading to more personalized treatment strategies for elderly patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults aged 75 and older who are at risk for cardiovascular disease.
Not a fit: Patients younger than 75 or those without risk factors for cardiovascular disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better prevention strategies for heart disease in older adults, ultimately improving their health outcomes.
How similar studies have performed: Previous research has shown promise in using CAC and hs-Tn for risk stratification, but this study aims to provide definitive evidence through a dedicated randomized trial.
Where this research is happening
Durham, United States
- Duke University — Durham, United States (Active)
Researchers
- Principal investigator: Daubert, Melissa — Duke University
- Study coordinator: Daubert, Melissa
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.