Evaluating changes in biliary tree health using advanced imaging techniques
Official title: DDT-BMQ-000146 Assessing clinically meaningful change in PSC as determined by quantitative MRCP (MRCP+) measured number of strictures
Funded at Perspectum Diagnostics, INC. · NIH-11087836 · Data updated 2026-11-12
This study is looking at new imaging techniques to help track how Primary Sclerosing Cholangitis (PSC) is changing in patients, so doctors can better understand how well treatments are working.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Perspectum Diagnostics, INC. NIH-funded |
| Lab location | 1 site (South San Francisco, United States) |
| Project start | September 1, 2024 |
| Project end | August 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $245,356 |
| NIH project number | 1U01FD008425-01 |
| Project ID | NIH-11087836 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Primary Sclerosing Cholangitis (PSC) who are undergoing treatment.
✕Less likely to help
Patients without a diagnosis of PSC or those who are not receiving treatment for biliary tree conditions may not benefit from this research.
What this research studies
This research investigates the use of MRCP+ metrics, which are advanced imaging markers of the biliary tree, to monitor disease progression in patients with Primary Sclerosing Cholangitis (PSC). By analyzing the number of strictures in the biliary tree, the study aims to establish these metrics as reliable indicators for assessing treatment responses in clinical trials. The research will involve a multi-center observational study with 150 participants, collecting both imaging and clinical data to understand how changes in these metrics correlate with patient outcomes. This approach could enhance the monitoring of PSC and improve treatment strategies.
Why it matters
Potential benefit: If successful, this research could provide a new tool for monitoring disease progression in PSC, leading to better treatment decisions and improved patient outcomes.
How similar studies have gone: Previous research has shown promise in using imaging biomarkers for monitoring biliary tree health, suggesting that this approach could be effective.
Where this research is happening
-
Perspectum Diagnostics, INC.
South San Francisco, United States Active
Researchers
- Principal investigator: Pandya, Prashant K — Perspectum Diagnostics, INC.
- Study coordinator: Pandya, Prashant K
Related research
Other NIH-funded projects on the same topics.
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Measuring liver health in patients with non-alcoholic steatohepatitis (NASH) without invasive procedures
This study is looking for a better way to check liver health in people with non-alcoholic steatohepatitis (NASH) using a special MRI technique, so you can avoid the discomfort of a liver biopsy while still getting accurate results.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.