Evaluating brain inflammation and metabolic stress in multiple sclerosis
PET and MRI Evaluation of Cerebral Inflammation and Metabolic Stress in Relapsing Multiple Sclerosis
This study is looking at how inflammation and stress in the body affect the progression of multiple sclerosis, especially for those with the relapsing type, to help find better ways to treat the disease.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project ID | NIH-10881978 on NIH RePORTER |
What this research studies
This research investigates the role of inflammation and metabolic stress in the progression of multiple sclerosis (MS), particularly in patients with relapsing forms of the disease. Using advanced imaging techniques, including PET scans with a novel agent, the study aims to identify markers of inflammation and metabolic changes in the brain. By understanding these factors, the research seeks to uncover the mechanisms behind neurodegeneration in MS, which often occurs even when patients are not experiencing relapses. This could lead to improved treatment strategies for managing the disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with relapsing multiple sclerosis who are experiencing or at risk of developing progressive forms of the disease.
Not a fit: Patients with primary progressive multiple sclerosis or those who do not have a diagnosis of multiple sclerosis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and management of multiple sclerosis, potentially improving outcomes for patients.
How similar studies have performed: Previous research has shown promising results using similar imaging techniques to assess inflammation and metabolic changes in neurological diseases, indicating potential for success in this approach.
Where this research is happening
Saint Louis, United States
- Washington University — Saint Louis, United States (Active)
Researchers
- Principal investigator: Brier, Matthew Ryan — Washington University
- Study coordinator: Brier, Matthew Ryan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.