Evaluating brain blood flow to predict stroke risk in patients with narrowed arteries
Non-invasive Evaluation of Intracranial Atherosclerotic Disease Using Hemodynamic Biomarkers
This study is looking at how new MRI techniques can help doctors understand blood flow and plaque stability in people with a condition that affects the arteries in the brain, with the goal of predicting who might be at risk for having another stroke, so they can receive better care.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Northwestern University at Chicago NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project ID | NIH-10687912 on NIH RePORTER |
What this research studies
This research investigates how advanced MRI techniques can be used to assess blood flow and plaque stability in patients with intracranial atherosclerotic disease (ICAD). By combining multiple imaging methods, including 4D flow MRI and perfusion-weighted MRI, the study aims to create a prediction model that identifies patients at risk for recurrent strokes. The approach integrates patient demographics and clinical factors to enhance the accuracy of risk assessments. This non-invasive evaluation could lead to better management and treatment strategies for affected individuals.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with intracranial atherosclerotic disease who are at risk for recurrent strokes.
Not a fit: Patients without intracranial atherosclerotic disease or those who have already experienced a stroke may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could significantly improve the ability to predict and prevent recurrent strokes in patients with narrowed brain arteries.
How similar studies have performed: Other research has shown promising results using advanced imaging techniques for assessing stroke risk, indicating that this approach has potential for success.
Where this research is happening
Chicago, United States
- Northwestern University at Chicago — Chicago, United States (Active)
Researchers
- Principal investigator: Markl, Michael — Northwestern University at Chicago
- Study coordinator: Markl, Michael
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.