Evaluating and predicting swallowing improvement in hospitalized Alzheimer's patients
Official title: A Prospective Observational Cohort Study to Evaluate and Predict Oropharyngeal Dysphagia (OD) Improvement in Hospitalized Patients with Alzheimer's disease and related Dementias (AD/ADRD)
Funded at Feinstein Institute for Medical Research · NIH-11054066 · Data updated 2026-11-12
This study is looking at how to help patients with Alzheimer's and related dementias who have trouble swallowing, by using a special computer program to predict which patients might get better before they leave the hospital, so that doctors can give them the best care and diet to improve their eating and overall well-being.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Feinstein Institute for Medical Research NIH-funded |
| Lab location | 1 site (Manhasset, United States) |
| Project start | June 15, 2025 |
| Project end | February 28, 2030 |
| Funding year | 2025 |
| Award (this year) | $852,049 |
| NIH project number | 1R01AG087104-01A1 |
| Project ID | NIH-11054066 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are hospitalized patients diagnosed with Alzheimer's disease or related dementias who are experiencing swallowing difficulties.
✕Less likely to help
Patients who do not have Alzheimer's disease or related dementias, or those who are not hospitalized, may not benefit from this research.
What this research studies
This research investigates oropharyngeal dysphagia (OD), a common swallowing difficulty in hospitalized patients with Alzheimer's disease and related dementias. The study aims to develop a machine-learning model to predict which patients are likely to improve in their swallowing ability before they are discharged from the hospital. By identifying these patients, healthcare providers can tailor their care and potentially adjust their diets to improve nutrition and quality of life. The research will also assess the impact of acute factors on swallowing difficulties and the need for reassessment before discharge.
Why it matters
Potential benefit: If successful, this research could lead to improved dietary management and quality of life for patients with Alzheimer's and related dementias.
How similar studies have gone: Previous research has shown promising results in using machine learning to predict clinical outcomes in similar patient populations, indicating potential for success in this approach.
Where this research is happening
-
Feinstein Institute for Medical Research
Manhasset, United States Active
Researchers
- Principal investigator: Sinvani, Liron Danay — Feinstein Institute for Medical Research
- Study coordinator: Sinvani, Liron Danay
Related research
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Engaging underrepresented individuals with Alzheimer's disease in swallowing research
This study is looking for ways to help people with Alzheimer's and related dementias who have trouble swallowing by teaming up with community groups to make sure everyone gets a chance to participate, so we can find better treatments that improve their swallowing and overall well-being.
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Improving swallowing function in patients with Alzheimer's and related dementias
This study is looking for new ways to help people with Alzheimer's and related dementias who have trouble swallowing, by training a speech therapist to create better treatments that can make eating and drinking safer and easier for them.
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Understanding how brain activity changes may drive Alzheimer’s disease progression in a mouse model
Researchers are testing how changes in brain signals and protein cleanup processes affect the development of Alzheimer’s disease in mice.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.