NIH-funded research R01 grant

Evaluating and predicting swallowing improvement in hospitalized Alzheimer's patients

Official title: A Prospective Observational Cohort Study to Evaluate and Predict Oropharyngeal Dysphagia (OD) Improvement in Hospitalized Patients with Alzheimer's disease and related Dementias (AD/ADRD)

Funded at Feinstein Institute for Medical Research · NIH-11054066 · Data updated 2026-11-12

This study is looking at how to help patients with Alzheimer's and related dementias who have trouble swallowing, by using a special computer program to predict which patients might get better before they leave the hospital, so that doctors can give them the best care and diet to improve their eating and overall well-being.

More s Disease research and trials

Quick facts

Grant typeR01 grant
Study typeNIH-funded research
Funding institutionFeinstein Institute for Medical Research
NIH-funded
Lab location1 site (Manhasset, United States)
Project startJune 15, 2025
Project endFebruary 28, 2030
Funding year2025
Award (this year)$852,049
NIH project number1R01AG087104-01A1
Project IDNIH-11054066 on NIH RePORTER

Who could benefit from this research

Could help

Ideal candidates for this research are hospitalized patients diagnosed with Alzheimer's disease or related dementias who are experiencing swallowing difficulties.

Less likely to help

Patients who do not have Alzheimer's disease or related dementias, or those who are not hospitalized, may not benefit from this research.

What this research studies

This research investigates oropharyngeal dysphagia (OD), a common swallowing difficulty in hospitalized patients with Alzheimer's disease and related dementias. The study aims to develop a machine-learning model to predict which patients are likely to improve in their swallowing ability before they are discharged from the hospital. By identifying these patients, healthcare providers can tailor their care and potentially adjust their diets to improve nutrition and quality of life. The research will also assess the impact of acute factors on swallowing difficulties and the need for reassessment before discharge.

Why it matters

Potential benefit: If successful, this research could lead to improved dietary management and quality of life for patients with Alzheimer's and related dementias.

How similar studies have gone: Previous research has shown promising results in using machine learning to predict clinical outcomes in similar patient populations, indicating potential for success in this approach.

Where this research is happening

  • Feinstein Institute for Medical Research
    Manhasset, United States
    Active

Researchers

  • Principal investigator: Sinvani, Liron Danay — Feinstein Institute for Medical Research
  • Study coordinator: Sinvani, Liron Danay

Related research

Other NIH-funded projects on the same topics.

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.