Evaluating a new vaccine to prevent pneumonia in young children
A Phase II Study Evaluating the Safety and Efficacy of Whole-Cell Pneumococcal Vaccine (wSp) in Reducing Nasopharyngeal Colonization by Streptococcus pneumoniae in Young Children
This study is testing a new vaccine for young children that aims to help their bodies fight off a common bacteria called Streptococcus pneumoniae, which can lead to serious illnesses, and it hopes to be a helpful addition to the vaccines already available.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rochester General Hospital (Ny) NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project ID | NIH-11056767 on NIH RePORTER |
What this research studies
This research investigates a new whole-cell pneumococcal vaccine designed to reduce the colonization of Streptococcus pneumoniae in young children. The vaccine is serotype-independent and aims to elicit a strong immune response, particularly targeting Th17 cell-mediated immunity. By vaccinating children, the study will assess the vaccine's safety and effectiveness in preventing nasopharyngeal colonization, which is a precursor to pneumococcal diseases. The research will also explore the potential of this vaccine to complement or replace existing pneumococcal conjugate vaccines.
Who could benefit from this research
Good fit: Ideal candidates for this research are young children, particularly those under 11 years old, who are at risk for pneumococcal infections.
Not a fit: Patients who are older than 21 years or those with existing severe pneumococcal infections may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to a more effective and cost-efficient vaccine for preventing pneumonia in children.
How similar studies have performed: Previous research has shown promise with similar whole-cell vaccine approaches, but this specific vaccine is novel and untested in this population.
Where this research is happening
Rochester, United States
- Rochester General Hospital (Ny) — Rochester, United States (Active)
Researchers
- Principal investigator: Pichichero, Michael E — Rochester General Hospital (Ny)
- Study coordinator: Pichichero, Michael E
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.