Evaluating a new type of vascular graft for congenital heart surgery
A Study Evaluating the Safety and Efficacy of Second-Generation Tissue Engineered Vascular Grafts (TEVG2)
['FUNDING_OTHER'] · RESEARCH INST NATIONWIDE CHILDREN'S HOSP · NIH-10589938
This study is testing a new type of blood vessel replacement made for kids who need heart surgery, to see if it works safely and effectively while growing naturally in their bodies.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | RESEARCH INST NATIONWIDE CHILDREN'S HOSP (nih funded) |
| Locations | 1 site (COLUMBUS, UNITED STATES) |
| Trial ID | NIH-10589938 on ClinicalTrials.gov |
What this research studies
This research focuses on a second-generation tissue engineered vascular graft (TEVG) specifically designed for children undergoing congenital heart surgery. The graft is created by seeding bone marrow-derived cells onto a biodegradable scaffold, which degrades over time, allowing the graft to develop into a blood vessel that mimics natural function and structure. The study aims to assess the safety and effectiveness of this new graft in a clinical trial involving 24 patients over two years, addressing previous issues with stenosis in earlier versions.
Who could benefit from this research
Good fit: Ideal candidates for this research are children with congenital heart defects who require surgical intervention.
Not a fit: Patients with non-congenital heart conditions or those who are not undergoing heart surgery may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to safer and more effective surgical options for children with congenital heart defects.
How similar studies have performed: Previous studies have shown promise with earlier versions of tissue engineered vascular grafts, but this second-generation approach aims to address specific limitations identified in those trials.
Where this research is happening
COLUMBUS, UNITED STATES
- RESEARCH INST NATIONWIDE CHILDREN'S HOSP — COLUMBUS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BREUER, CHRISTOPHER KANE — RESEARCH INST NATIONWIDE CHILDREN'S HOSP
- Study coordinator: BREUER, CHRISTOPHER KANE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.