Evaluating a new treatment for tuberculosis
Official title: EPCTU: A Study to Evaluate the Pharmacokinetics and Safety of a Therapeutic for Tuberculosis
Funded at Icon Government and Public Health Solutions, INC. · NIH-10912971 · Data updated 2026-11-12
This study is looking at a new medication for tuberculosis to see how well it works and if it's safe for people with the condition, and you'll be helping us learn more by trying it out in a clinical trial.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icon Government and Public Health Solutions, INC. NIH-funded |
| Lab location | 1 site (Hinckley, United States) |
| Project start | July 5, 2023 |
| Project end | July 14, 2025 |
| Funding year | 2023 |
| Award (this year) | $1,962,150 |
| NIH project number | 75N93022D00018-0-759302300001-1 |
| Project ID | NIH-10912971 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with tuberculosis who are seeking new treatment options.
✕Less likely to help
Patients who do not have tuberculosis or those who are not eligible for clinical trials may not benefit from this research.
What this research studies
This research investigates the pharmacokinetics and safety of a new therapeutic agent aimed at treating tuberculosis. Patients will receive the treatment, and researchers will closely monitor how the drug is absorbed, distributed, metabolized, and excreted in the body. The study aims to ensure that the new therapy is both effective and safe for individuals suffering from tuberculosis. Participants will be involved in a clinical trial that assesses various aspects of the treatment's performance.
Why it matters
Potential benefit: If successful, this research could lead to more effective and safer treatments for tuberculosis, improving patient outcomes.
How similar studies have gone: Other research has shown success in evaluating new treatments for tuberculosis, indicating that this approach is promising.
Where this research is happening
-
Icon Government and Public Health Solutions, INC.
Hinckley, United States Active
Researchers
- Principal investigator: Spitz, Robert — Icon Government and Public Health Solutions, INC.
- Study coordinator: Spitz, Robert
Related research
Other NIH-funded projects on the same topics.
-
Urine color test to check tuberculosis drug levels in children and adults
This project uses a simple urine color test to see whether children and adults with TB are getting enough of key TB medicines like rifampin.
-
Treatment options for isoniazid-resistant TB: safety, effectiveness, and drug levels with a standard regimen
This grant studies whether a standard TB treatment plan that includes levofloxacin is safe and effective for people with isoniazid-resistant TB in Peru.
-
How lung cavities and granulomas affect TB inflammation and drug levels
This project looks at how damaged lung areas in people with pulmonary tuberculosis influence inflammation and whether antibiotics reach those spots.
-
Urine color test to monitor TB medicine levels in children and adults
This project uses a simple urine color measurement to check how well TB medicines, especially rifampin, reach the body in children and adults.
-
Finding better ways to diagnose tuberculosis in young children in Malawi.
This study is looking for better ways to find tuberculosis in young children under five in Malawi, especially those who are very malnourished, to help improve their treatment and care.
-
Evaluating a new treatment for antibiotic-resistant tuberculosis
This study is looking at a new treatment for antibiotic-resistant tuberculosis to see how well it works and how safe it is for patients, so we can find better options for people dealing with this tough infection.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.