Evaluating a new treatment for antibiotic-resistant tuberculosis
Official title: Task C1D1: A Study to Evaluate the Pharmacokinetics and Safety of a Therapeutic for Antibiotic-Resistant Tuberculosis
Funded at Icon Government and Public Health Solutions, INC. · NIH-11166262 · Data updated 2026-11-12
This study is looking at a new treatment for antibiotic-resistant tuberculosis to see how well it works and how safe it is for patients, so we can find better options for people dealing with this tough infection.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icon Government and Public Health Solutions, INC. NIH-funded |
| Lab location | 1 site (Hinckley, United States) |
| Project start | July 5, 2023 |
| Project end | July 14, 2025 |
| Funding year | 2024 |
| Award (this year) | $59,004 |
| NIH project number | 75N93022D00018-P00002-759302300001-1 |
| Project ID | NIH-11166262 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with antibiotic-resistant tuberculosis.
✕Less likely to help
Patients who do not have tuberculosis or those with drug-sensitive strains of the disease may not benefit from this research.
What this research studies
This research investigates a new therapeutic approach for treating antibiotic-resistant tuberculosis by evaluating how the drug is processed in the body and its safety profile. Patients will be monitored closely during the trial to assess the drug's effectiveness and any potential side effects. The study aims to provide critical data that could lead to improved treatment options for those suffering from this challenging infection.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for patients with antibiotic-resistant tuberculosis.
How similar studies have gone: Other research has shown promise in developing new treatments for antibiotic-resistant infections, indicating potential for success in this area.
Where this research is happening
-
Icon Government and Public Health Solutions, INC.
Hinckley, United States Active
Researchers
- Principal investigator: Spitz, Robert — Icon Government and Public Health Solutions, INC.
- Study coordinator: Spitz, Robert
Related research
Other NIH-funded projects on the same topics.
-
Urine color test to check tuberculosis drug levels in children and adults
This project uses a simple urine color test to see whether children and adults with TB are getting enough of key TB medicines like rifampin.
-
Treatment options for isoniazid-resistant TB: safety, effectiveness, and drug levels with a standard regimen
This grant studies whether a standard TB treatment plan that includes levofloxacin is safe and effective for people with isoniazid-resistant TB in Peru.
-
How lung cavities and granulomas affect TB inflammation and drug levels
This project looks at how damaged lung areas in people with pulmonary tuberculosis influence inflammation and whether antibiotics reach those spots.
-
Urine color test to monitor TB medicine levels in children and adults
This project uses a simple urine color measurement to check how well TB medicines, especially rifampin, reach the body in children and adults.
-
Finding better ways to diagnose tuberculosis in young children in Malawi.
This study is looking for better ways to find tuberculosis in young children under five in Malawi, especially those who are very malnourished, to help improve their treatment and care.
-
Improving treatment for isoniazid-resistant tuberculosis
This project tests whether replacing isoniazid with levofloxacin and adjusting doses gives safer, more effective treatment for adults with isoniazid-resistant TB.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.