Evaluating a new imaging technique for monitoring prostate cancer in men on active surveillance
Official title: ESCAPE - Evaluation of Prostate Specific Membrane Antigen Positron Emission Tomography-Computed Tomography in Active Surveillance for Prostate Cancer
Funded at Weill Medical Coll of Cornell Univ · NIH-11052535 · Data updated 2026-11-12
This study is looking at how a special imaging test called PSMA PET-CT can help doctors better monitor prostate cancer in men who are being watched closely instead of treated right away, with the goal of reducing unnecessary treatments and side effects for those with low-risk cancer.
Quick facts
| Grant type | R37 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Weill Medical Coll of Cornell Univ NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | April 1, 2024 |
| Project end | March 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $698,716 |
| NIH project number | 5R37CA282407-02 |
| Project ID | NIH-11052535 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are men diagnosed with low-risk prostate cancer who are currently on active surveillance.
✕Less likely to help
Patients with high-risk prostate cancer or those who have already undergone definitive treatment may not benefit from this research.
What this research studies
This research investigates the use of Prostate Specific Membrane Antigen Positron Emission Tomography-Computed Tomography (PSMA PET-CT) to improve the monitoring of prostate cancer in men who are on active surveillance. The study aims to optimize the protocols for active surveillance by assessing the accuracy of PSMA PET-CT in detecting clinically significant prostate cancer compared to traditional methods like biopsies and PSA measurements. By focusing on minimizing unnecessary treatments and their associated side effects, the research seeks to enhance patient care and outcomes for those with low-risk prostate cancer.
Why it matters
Potential benefit: If successful, this research could lead to more accurate monitoring of prostate cancer, reducing unnecessary treatments and improving quality of life for patients.
How similar studies have gone: Previous research has shown that advanced imaging techniques like MRI can improve detection rates of clinically significant prostate cancer, suggesting potential success for this novel approach.
Where this research is happening
-
Weill Medical Coll of Cornell Univ
New York, United States Active
Researchers
- Principal investigator: Mcclure, Timothy — Weill Medical Coll of Cornell Univ
- Study coordinator: Mcclure, Timothy
Related research
Other NIH-funded projects on the same topics.
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Using PSMA PET-CT scans to improve monitoring during active surveillance for prostate cancer
This project checks whether adding PSMA PET-CT scans helps find aggressive prostate cancer earlier in men who are being closely watched instead of treated.
-
Cardiovascular risk planning and reduction for men with prostate cancer
A program to better predict and reduce heart disease risk in men treated for prostate cancer, especially older patients.
-
Effects of ADT on motivation and emotion in prostate cancer patients
This project looks at how androgen deprivation therapy may affect motivation and mood over time in men with prostate cancer.
-
Causal Protein Markers to Understand and Predict Prostate Cancer Risk in Africans and Europeans
A cancer research project looking at proteins linked to prostate cancer to better understand why it happens and how risk differs between African and European populations.
-
Ethical multimodal AI platform to improve prostate cancer detection with ultrasound
A patient-friendly AI system uses ultrasound and MRI information to help doctors better find prostate cancer, aiming to improve accuracy and access.
-
Characterizing epigenetic targets in prostate cancer to help AR-driven cancer
A research project at MD Anderson aims to understand how epigenetic factors shape androgen receptor signaling in prostate cancer to find new ways to treat resistant forms of the disease.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.