Estimating treatment benefits of hormone therapy for men with prostate cancer
Official title: Individualized estimates of treatment benefit from hormone therapy for men with prostate cancer
Funded at University of Michigan at Ann Arbor · NIH-10739866 · Data updated 2026-11-12
This study is looking to help men with localized prostate cancer understand how hormone therapy might work for them by considering their unique health situations and backgrounds, so they can make better choices about their treatment.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project start | September 20, 2023 |
| Project end | August 31, 2025 |
| Funding year | 2023 |
| Award (this year) | $386,866 |
| NIH project number | 1R21CA274500-01A1 |
| Project ID | NIH-10739866 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are men diagnosed with localized prostate cancer who are considering hormone therapy as part of their treatment.
✕Less likely to help
Patients with advanced prostate cancer or those who are not considering hormone therapy may not benefit from this research.
What this research studies
This research aims to create personalized estimates of treatment benefits from hormone therapy for men diagnosed with localized prostate cancer. By analyzing data from the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial, the study focuses on understanding how other health conditions and demographics influence life expectancy and treatment outcomes. The goal is to develop a model that helps doctors and patients make informed decisions about hormone therapy based on individual risk factors and potential benefits.
Why it matters
Potential benefit: If successful, this research could lead to more tailored treatment plans for men with prostate cancer, improving their quality of life and survival rates.
How similar studies have gone: Previous research has shown promise in developing individualized treatment models for cancer patients, indicating that this approach could be effective.
Where this research is happening
-
University of Michigan at Ann Arbor
Ann Arbor, United States Active
Researchers
- Principal investigator: Schipper, Matthew — University of Michigan at Ann Arbor
- Study coordinator: Schipper, Matthew
Related research
Other NIH-funded projects on the same topics.
-
Cardiovascular risk planning and reduction for men with prostate cancer
A program to better predict and reduce heart disease risk in men treated for prostate cancer, especially older patients.
-
Effects of ADT on motivation and emotion in prostate cancer patients
This project looks at how androgen deprivation therapy may affect motivation and mood over time in men with prostate cancer.
-
Causal Protein Markers to Understand and Predict Prostate Cancer Risk in Africans and Europeans
A cancer research project looking at proteins linked to prostate cancer to better understand why it happens and how risk differs between African and European populations.
-
Ethical multimodal AI platform to improve prostate cancer detection with ultrasound
A patient-friendly AI system uses ultrasound and MRI information to help doctors better find prostate cancer, aiming to improve accuracy and access.
-
Characterizing epigenetic targets in prostate cancer to help AR-driven cancer
A research project at MD Anderson aims to understand how epigenetic factors shape androgen receptor signaling in prostate cancer to find new ways to treat resistant forms of the disease.
-
AR and RNA-binding in prostate cancer resistance
A cancer research grant exploring how the androgen receptor’s interaction with RNA may drive treatment resistance in prostate cancer, with potential to guide new therapies.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.