EPPIC‑Net: Early testing of new non‑addictive pain treatments
EPPIC-Net Pain Research - Application for Clinical Trial and Related Activities (OT2)
This project tests new non‑opioid medicines and devices to help adults with moderate to severe pain, such as knee osteoarthritis pain.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts General Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11376471 on NIH RePORTER |
What this research studies
You would be part of a national network that quickly designs and runs early‑phase clinical trials of promising non‑addictive pain treatments. The network collects detailed patient information and biomarkers to better match treatments to people with clearly defined pain conditions. One example trial in the network is a 24‑week oral medication study for adults with moderate to severe knee osteoarthritis pain involving about 150 participants at multiple U.S. sites. The program focuses on short, carefully monitored early trials to find safe and potentially effective options before larger studies.
Who could benefit from this research
Good fit: Adults (21+) with clearly defined, moderate to severe pain conditions—for example knee osteoarthritis pain—who can attend study visits at participating U.S. sites and meet trial eligibility criteria are ideal candidates.
Not a fit: People without the specific targeted pain condition (for example those without knee osteoarthritis), children, or anyone who does not meet the trial eligibility requirements would be unlikely to benefit from participation.
Why it matters
Potential benefit: If successful, this work could lead to new non‑addictive pain treatments that reduce reliance on opioids and relieve pain for people with conditions like knee osteoarthritis.
How similar studies have performed: Some early‑phase trials of non‑opioid pain treatments have shown promise in preclinical and small clinical studies, but many approaches remain unproven in larger trials.
Where this research is happening
Boston, United States
- Massachusetts General Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Fava, Maurizio — Massachusetts General Hospital
- Study coordinator: Fava, Maurizio
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.