Epigenetic factors that keep adult skin stem cells healthy
Official title: Identifying epigenetic factors in control of epidermal stem cell longevity in the adult skin
Funded at University of California Riverside · NIH-11416587 · Data updated 2026-11-12
Researchers are studying how epigenetic changes help skin stem cells in adults stay healthy and support skin repair as we age.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Riverside NIH-funded |
| Lab location | 1 site (Riverside, United States) |
| Project start | September 15, 2025 |
| Project end | August 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $231,019 |
| NIH project number | 5R00AR082956-04 |
| Project ID | NIH-11416587 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with aging skin or age‑related skin healing problems who could participate in related future studies.
✕Less likely to help
Individuals without aging-related skin issues may not directly benefit from this research.
What this research studies
This project looks at how skin stem cells in adults maintain their longevity and function, especially in aging skin. It will examine epigenetic regulators in mammalian skin to understand how aging affects the basal and hair follicle stem cell pools. The study uses in vivo loss‑of‑function approaches to explore whether chromatin changes influence stem cell longevity and tissue repair in the adult skin. The goal is to uncover mechanisms that could someday improve skin health and wound healing in aging individuals.
Why it matters
Potential benefit: If successful, findings could lead to new approaches to preserve skin integrity and healing in aging people.
How similar studies have gone: Prior mammalian studies suggest epigenetic regulation affects aging; this project tests these ideas directly in human-relevant skin stem cells.
Where this research is happening
-
University of California Riverside
Riverside, United States Active
Researchers
- Principal investigator: Flora, Pooja — University of California Riverside
- Study coordinator: Flora, Pooja
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.