EPHB2 signaling in Barrett's esophagus and esophageal cancer
EPHB2-Dependent Signaling: A New Molecular Paradigm in Barrett's Neoplasia
This project is testing whether a protein called EphB2 drives Barrett's esophagus and its progression to esophageal cancer, with the goal of helping people with Barrett's.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Case Western Reserve University NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project ID | NIH-11179400 on NIH RePORTER |
What this research studies
From a patient's point of view, researchers will examine tissue samples from people with Barrett's esophagus and early esophageal cancer to see how active the EphB2 protein is. They'll use advanced gene sequencing on those biopsies and single-cell analyses to find which cells show EphB2-driven changes. In the lab they will use cell and animal models to test whether blocking EphB2 affects the survival or behavior of Barrett's and cancer cells. The team aims to translate these findings into biomarkers and possible prevention or treatment strategies for patients.
Who could benefit from this research
Good fit: Ideal candidates would be people diagnosed with Barrett's esophagus, especially those with dysplasia or undergoing surveillance endoscopy who can provide biopsy samples.
Not a fit: People without Barrett's esophagus or esophageal cancer are unlikely to receive direct benefit from this project.
Why it matters
Potential benefit: If successful, this work could lead to new biomarkers for earlier detection and new targeted prevention or treatment approaches for people with Barrett's esophagus and early esophageal cancer.
How similar studies have performed: This builds on a new discovery linking EphB2 to Barrett's and esophageal cancer and represents an early-stage, translational research direction with limited prior clinical testing.
Where this research is happening
Cleveland, United States
- Case Western Reserve University — Cleveland, United States (Active)
Researchers
- Principal investigator: Blum, Andrew Edward — Case Western Reserve University
- Study coordinator: Blum, Andrew Edward
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.