Eosinophils help the immune system fight respiratory bacterial infections.
Eosinophils facilitate bacterial clearance by mediating antibacterial T cell responses in the respiratory tract
['FUNDING_OTHER'] · LOUISIANA STATE UNIV HSC SHREVEPORT · NIH-11041017
This study is looking at how a type of immune cell called eosinophils helps the body fight off bacterial infections like Whooping cough, and it could help improve vaccines to better protect against respiratory illnesses.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | LOUISIANA STATE UNIV HSC SHREVEPORT (nih funded) |
| Locations | 1 site (SHREVEPORT, UNITED STATES) |
| Trial ID | NIH-11041017 on ClinicalTrials.gov |
What this research studies
This research investigates how eosinophils, a type of immune cell, contribute to the body's ability to clear bacterial infections in the respiratory tract, particularly focusing on Whooping cough. By using a mouse model infected with Bordetella bronchiseptica, the study aims to understand the role of eosinophils in activating T cells and enhancing the immune response. The findings could lead to improved vaccine strategies that not only generate antibody responses but also enhance T cell and mucosal immunity against respiratory pathogens.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research are children under 11 years old, particularly those at risk for respiratory infections.
Not a fit: Patients who are adults or do not have respiratory infections may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective vaccines and treatments for respiratory infections in children.
How similar studies have performed: Other research has shown that eosinophils play significant roles in immune responses, suggesting that this approach could yield valuable insights.
Where this research is happening
SHREVEPORT, UNITED STATES
- LOUISIANA STATE UNIV HSC SHREVEPORT — SHREVEPORT, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: GESTAL, MONICA CARTELLE — LOUISIANA STATE UNIV HSC SHREVEPORT
- Study coordinator: GESTAL, MONICA CARTELLE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Airway infections