Environmental exposures and early familial pulmonary fibrosis
Project 2: Environmental exposures in pre-clinical FPF
Researchers are looking at whether lifetime environmental exposures are linked to early lung changes in adults who have family members with pulmonary fibrosis.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project ID | NIH-11193842 on NIH RePORTER |
What this research studies
If you join, the team will follow adults who have relatives with pulmonary fibrosis and collect chest CT scans, blood samples, and detailed exposure histories. They will measure air pollutants and other lifetime exposures and link those to imaging findings called interstitial lung abnormalities and to biological markers in blood and tissue. The project combines advanced 'omics' testing with clinical imaging to see how exposures might influence early disease processes. Participants will be followed over time with repeat scans and sample collection to track any progression.
Who could benefit from this research
Good fit: Adults (age 21+) who are relatives of someone with pulmonary fibrosis, including those without symptoms, are the intended participants.
Not a fit: People without a family history of pulmonary fibrosis or those already living with advanced, symptomatic PF are unlikely to gain direct benefit from joining.
Why it matters
Potential benefit: If successful, this work could help identify harmful exposures and earlier signs of pulmonary fibrosis so people at risk can be monitored or offered prevention strategies.
How similar studies have performed: Earlier research has shown that relatives can have subtle CT changes years before symptoms, but combining detailed lifetime exposure data with molecular and imaging markers is relatively new.
Where this research is happening
Ann Arbor, United States
- University of Michigan at Ann Arbor — Ann Arbor, United States (Active)
Researchers
- Principal investigator: Salisbury, Margaret Louise — University of Michigan at Ann Arbor
- Study coordinator: Salisbury, Margaret Louise
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.