Entorhinal cortex slow rhythms and long-term memory in Alzheimer's
Official title: Role of the Entorhinal Cortical Delta Oscillations in Systems Consolidation
Funded at Louisiana State Univ A&m Col Baton Rouge · NIH-11370125 · Data updated 2026-11-12
This work looks at how slow brain waves in a region called the entorhinal cortex help form long-term memories and how problems with those waves may lead to memory loss in Alzheimer's disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Louisiana State Univ A&m Col Baton Rouge NIH-funded |
| Lab location | 1 site (Baton Rouge, United States) |
| Project start | May 15, 2025 |
| Project end | February 28, 2030 |
| Funding year | 2026 |
| Award (this year) | $369,056 |
| NIH project number | 5R01MH140001-02 |
| Project ID | NIH-11370125 on NIH RePORTER |
Who could benefit from this research
✓Could help
People with early-stage Alzheimer's disease or mild cognitive impairment (MCI), or those at high risk of Alzheimer's, would be the most likely candidates for future therapies arising from this work.
✕Less likely to help
People with very advanced dementia, memory loss from non‑Alzheimer causes, or unrelated neurological conditions are less likely to benefit directly from this research in the near term.
What this research studies
From a patient point of view, researchers are studying how specific slow brain rhythms support the transfer of new memories into long-lasting memory storage and why that process fails in Alzheimer's. The team uses laboratory experiments that record and manipulate brain activity in models to see how entorhinal signals influence the hippocampus and cortex during sleep and quiet rest. They focus on the temporoammonic pathway and delta oscillations to pinpoint circuit-level changes that disrupt memory consolidation. Findings aim to reveal mechanisms that could be targeted to protect or restore memory function in people with Alzheimer's.
Why it matters
Potential benefit: If successful, this work could identify new brain rhythms or circuit targets that lead to treatments or devices to improve memory consolidation in Alzheimer's disease.
How similar studies have gone: Prior research has linked hippocampal sharp‑wave ripples and sleep rhythms to memory consolidation, but focusing on entorhinal delta oscillations as a therapeutic target is a newer and still-developing approach.
Where this research is happening
-
Louisiana State Univ A&m Col Baton Rouge
Baton Rouge, United States Active
Researchers
- Principal investigator: Haam, Juhee — Louisiana State Univ A&m Col Baton Rouge
- Study coordinator: Haam, Juhee
Related research
Other NIH-funded projects on the same topics.
-
Bilateral auditory integration and its role in auditory disorders
A study to understand how both ears work together to localize and organize sounds, which could help people with central auditory processing issues.
-
Host glutamine metabolism in tuberculosis pathogenesis
A study tests a drug that blocks host glutamine use to help fight tuberculosis by improving immune cells’ ability to kill the bacteria.
-
Ras signaling and regulatory T cells to treat allergic airway inflammation
A small, patient-friendly study will explore how Ras signaling affects a type of immune cell that helps control allergic inflammation in the airways of people with allergic asthma.
-
Bacterial genome sequencing to boost AMR detection in veterinary-lab networks
A veterinary and public-health project to expand bacterial whole-genome sequencing so labs can quickly identify antibiotic resistance and control outbreaks.
-
Microbes and the body's hormonal signals in a tiny worm
This grant looks at how gut microbes affect hormonal signals that control metabolism, using a tiny worm to model how this could influence type 2 diabetes and related heart and kidney issues.
-
Leptin and fat cells: how obesity may worsen lung infections like COVID-19 and flu
A study explores how fat tissue and the leptin pathway might change the body's first lung defenses during respiratory infections in people who are obese or have diabetes.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.