Entorhinal cortex slow rhythms and long-term memory in Alzheimer's
Role of the Entorhinal Cortical Delta Oscillations in Systems Consolidation
This work looks at how slow brain waves in a region called the entorhinal cortex help form long-term memories and how problems with those waves may lead to memory loss in Alzheimer's disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Louisiana State Univ A&m Col Baton Rouge NIH-funded |
| Lab location | 1 site (Baton Rouge, United States) |
| Project ID | NIH-11370125 on NIH RePORTER |
What this research studies
From a patient point of view, researchers are studying how specific slow brain rhythms support the transfer of new memories into long-lasting memory storage and why that process fails in Alzheimer's. The team uses laboratory experiments that record and manipulate brain activity in models to see how entorhinal signals influence the hippocampus and cortex during sleep and quiet rest. They focus on the temporoammonic pathway and delta oscillations to pinpoint circuit-level changes that disrupt memory consolidation. Findings aim to reveal mechanisms that could be targeted to protect or restore memory function in people with Alzheimer's.
Who could benefit from this research
Good fit: People with early-stage Alzheimer's disease or mild cognitive impairment (MCI), or those at high risk of Alzheimer's, would be the most likely candidates for future therapies arising from this work.
Not a fit: People with very advanced dementia, memory loss from non‑Alzheimer causes, or unrelated neurological conditions are less likely to benefit directly from this research in the near term.
Why it matters
Potential benefit: If successful, this work could identify new brain rhythms or circuit targets that lead to treatments or devices to improve memory consolidation in Alzheimer's disease.
How similar studies have performed: Prior research has linked hippocampal sharp‑wave ripples and sleep rhythms to memory consolidation, but focusing on entorhinal delta oscillations as a therapeutic target is a newer and still-developing approach.
Where this research is happening
Baton Rouge, United States
- Louisiana State Univ A&m Col Baton Rouge — Baton Rouge, United States (Active)
Researchers
- Principal investigator: Haam, Juhee — Louisiana State Univ A&m Col Baton Rouge
- Study coordinator: Haam, Juhee
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.