Enhancing the immune system's ability to fight cancer using CD4 T cells
Reviving cancer immune surveillance with CD4 T cell help
This study is looking at a way to help your immune system fight cancer better by using special cells that were trained by vaccines you might have received as a child, and it’s for people with cancer who want to explore new treatment options.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Duke University NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project ID | NIH-10862804 on NIH RePORTER |
What this research studies
This research investigates how to boost the immune system's response to cancer by reactivating specific CD4 T cells that were trained by childhood vaccines. The approach involves injecting a recall antigen directly into tumors to stimulate these helper T cells, which can enhance the activity of other immune cells that attack cancer. By understanding how these CD4 T cells can trigger a stronger immune response, the research aims to develop new therapies that could improve outcomes for cancer patients. The study will analyze the changes in immune cell behavior and their effectiveness in combating tumors.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients with advanced cancers who may benefit from enhanced immune responses.
Not a fit: Patients with cancers that do not respond to immune therapies or those who are not eligible for immunotherapy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new immunotherapy treatments that significantly improve cancer outcomes for patients.
How similar studies have performed: Other research has shown promising results in using immune system reactivation strategies, suggesting that this approach could be effective.
Where this research is happening
Durham, United States
- Duke University — Durham, United States (Active)
Researchers
- Principal investigator: Brown, Michael Clavon — Duke University
- Study coordinator: Brown, Michael Clavon
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.