Enhancing the immune response in the omentum to prevent cancer spread
Official title: Boosting anti-tumor immunity in the omentum for metastasis prevention
Funded at University of Tx Md Anderson Can Ctr · NIH-10835982 · Data updated 2026-11-12
This study is looking at how a special fatty tissue near the stomach can help fight ovarian cancer by boosting the immune system's ability to target cancer cells, which could lead to better treatments for patients.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Tx Md Anderson Can Ctr NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project start | May 2, 2023 |
| Project end | April 30, 2026 |
| Funding year | 2024 |
| Award (this year) | $215,846 |
| NIH project number | 5R21CA273656-02 |
| Project ID | NIH-10835982 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients with ovarian cancer, particularly those at risk of metastasis to the omentum.
✕Less likely to help
Patients with advanced metastatic ovarian cancer who have already experienced significant spread may not benefit from this research.
What this research studies
This research focuses on understanding how the omentum, a fatty tissue near the stomach, can be better utilized to fight against ovarian cancer metastasis. The study investigates the role of immune cells, particularly neutrophils, in the omentum and how they can be manipulated to enhance anti-tumor immunity. By exploring the mechanisms that allow cancer cells to thrive in this environment, the researchers aim to develop new therapeutic strategies that could prevent the spread of cancer to the omentum. Patients may benefit from treatments that improve their immune response against cancer cells in this critical area.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that significantly reduce the risk of ovarian cancer metastasis to the omentum, improving patient outcomes.
How similar studies have gone: While this approach is innovative, previous studies have shown promise in enhancing immune responses against tumors, suggesting potential for success.
Where this research is happening
-
University of Tx Md Anderson Can Ctr
Houston, United States Active
Researchers
- Principal investigator: Naora, Honami — University of Tx Md Anderson Can Ctr
- Study coordinator: Naora, Honami
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.