Enhancing immune response to treat colon cancer metastases
Stimulating Lymphocyte Activation Combined with Inhibition of Immunosuppressive Signals in Colon Cancer Metastases
This study is looking at ways to help your immune system better fight colon cancer and stop it from spreading to the liver by changing the tumor environment and using new treatment combinations, so it’s designed for people with colon cancer who want to explore more effective options.
Quick facts
| Grant type | R37 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project ID | NIH-10881162 on NIH RePORTER |
What this research studies
This research investigates how to improve the immune system's ability to fight colon cancer and its spread to the liver. The approach focuses on manipulating the tumor environment to increase the infiltration and activation of immune cells, particularly cytotoxic lymphocytes. By combining this with therapies that block immunosuppressive signals, the researchers aim to create a more effective treatment strategy for patients with colon cancer. The study will explore specific mechanisms to enhance immune responses and test new treatment combinations in pre-clinical models.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults diagnosed with colon cancer or colorectal liver metastases, particularly those with microsatellite stable tumors.
Not a fit: Patients with other types of cancer or those who are not adults may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective immunotherapy treatments for patients with colon cancer and colorectal liver metastases.
How similar studies have performed: Previous research has shown promise in using immunotherapy approaches for cancer treatment, suggesting that this combined strategy may also be effective.
Where this research is happening
San Francisco, United States
- University of California, San Francisco — San Francisco, United States (Active)
Researchers
- Principal investigator: Maker, Ajay V. — University of California, San Francisco
- Study coordinator: Maker, Ajay V.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.